The wife of Iran’s Supreme Leader, Ayatollah Seyyed Ali Khamenei, Mansoureh Khojasteh Bagherzadeh, has passed away, according to a statement from Iranian media.

According to information, she had fallen into a coma on February 28 during the military air strikes carried out by the U.S. and Israel, The Caspian Post reports.

The escalation follows the 3rd round of nuclear talks between Iran and the United States in Geneva on February 26. Held under the administration of U.S. President Donald Trump, the negotiations were viewed as the final chance to strike a deal diplomatically. However, no agreements were reached, as Tehran refused to halt uranium enrichment, dismantle its nuclear facilities, or accept indefinite restrictions on its nuclear program. Israel launched its airstrikes shortly afterward, with the country's Defense Minister Katz emphasizing that the operations were preemptive.